ABSTRACT
Gastrointestinal tract contains a wide variety of host-specific microbial communities that not only adapt to the unique and diverse environment in the stomach and intestine, but also respond quickly to all kinds of variants from outside of the body. A series of biochemical signals are occurred for interacting with the host to coordinate the exchange of nutrients and regulate the immune function. The interaction between host and microorganisms is based on homeostasis; dysbiosis of intestinal microbiota contributes to the initiation and development of diseases. The relationship between microbes and host from the perspective of microecology, and the relationship between intestinal microecology and digestive system diseases were summarized in this article.
ABSTRACT
Objective To explore the relationship between the Interleukin 6 , matrix metalloproteinases 2 and early embryo arrest. Methods Real time-PCR was used to measure the mRNA expression of IL-6 and MMP-2 and immunohistochemistry (IHC, SP method)was used to measure the location and expression of the two different kinds of protein in villus. ELISA was used to measure the level of IL-6 in serum. Results Real-time PCR and IHC showed that the expression levels of IL-6 was significantly lower in experimental group than in control group, and MMP-2 was significantly higher than the control group (P 0.05). Conclusion Proper expressions of IL-6 and MMP-2 in the villus tissue play a key role in the maintenance of early pregnancy.